全文获取类型
收费全文 | 16490篇 |
免费 | 1108篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 164篇 |
儿科学 | 628篇 |
妇产科学 | 670篇 |
基础医学 | 2019篇 |
口腔科学 | 230篇 |
临床医学 | 2745篇 |
内科学 | 2771篇 |
皮肤病学 | 343篇 |
神经病学 | 1388篇 |
特种医学 | 265篇 |
外科学 | 1498篇 |
综合类 | 306篇 |
一般理论 | 17篇 |
预防医学 | 2058篇 |
眼科学 | 361篇 |
药学 | 1009篇 |
中国医学 | 20篇 |
肿瘤学 | 1128篇 |
出版年
2023年 | 100篇 |
2022年 | 78篇 |
2021年 | 369篇 |
2020年 | 303篇 |
2019年 | 398篇 |
2018年 | 424篇 |
2017年 | 314篇 |
2016年 | 360篇 |
2015年 | 412篇 |
2014年 | 559篇 |
2013年 | 826篇 |
2012年 | 1296篇 |
2011年 | 1404篇 |
2010年 | 736篇 |
2009年 | 592篇 |
2008年 | 1180篇 |
2007年 | 1228篇 |
2006年 | 1136篇 |
2005年 | 1159篇 |
2004年 | 1100篇 |
2003年 | 1053篇 |
2002年 | 846篇 |
2001年 | 107篇 |
2000年 | 87篇 |
1999年 | 87篇 |
1998年 | 146篇 |
1997年 | 136篇 |
1996年 | 89篇 |
1995年 | 91篇 |
1994年 | 93篇 |
1993年 | 84篇 |
1992年 | 62篇 |
1991年 | 60篇 |
1990年 | 58篇 |
1989年 | 56篇 |
1988年 | 43篇 |
1987年 | 35篇 |
1986年 | 50篇 |
1985年 | 42篇 |
1984年 | 62篇 |
1983年 | 51篇 |
1982年 | 54篇 |
1981年 | 42篇 |
1980年 | 48篇 |
1979年 | 33篇 |
1978年 | 28篇 |
1977年 | 20篇 |
1976年 | 14篇 |
1974年 | 13篇 |
1972年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 250 毫秒
61.
Paul Fefer Roy Beigel Nurit Rosenberg Michael Shechter Sharon Gannot David Varon 《Platelets》2015,26(2):127-131
High-post clopidogrel platelet reactivity in acute coronary syndrome (ACS) patients is associated with adverse outcomes and may be related to clopidogrel dosing. Clinical studies evaluating different clopidogrel doses have resulted in conflicting conclusions. Clopidogrel dosing regimens have evolved over time, enabling us to evaluate platelet reactivity in real-life ACS patients undergoing percutaneous coronary intervention and treated with three different clopidogrel doses. Platelet reactivity was assessed with light transmitted aggregometry on the third day post clopidogrel loading in 404 consecutive ACS patients. Of them, 198 were treated with a standard regimen (300?mg loading, 75?mg/day maintenance dose), 95 with a high loading regimen (600?mg loading, 75?mg/day maintenance dose) and 111 with a high loading/high maintenance regimen (600?mg loading, 150?mg/day maintenance). Compared with the standard regimen, the high loading regimen resulted in significantly lower mean platelet reactivity to adenosine diphosphate (ADP) with a lower proportion of patients exhibiting clopidogrel non-responsiveness (11% vs. 28%, p?=?0.004). Compared with the high loading regimen, the high loading/high maintenance regimen resulted in significantly lower mean platelet reactivity to ADP, but without a further drop in the number of non-responders (8.1% vs. 11%, p?=?0.16). In conclusion, greater overall inhibition can be achieved with higher loading and maintenance doses in ACS patients. However, despite high clopidogrel doses, a sizable proportion of patients remained “resistant” to the effects of clopidogrel. 相似文献
62.
Sharon Seivert 《Nurse Leader》2004,2(3):54-55
The world is experiencing a global shortage of nurses, and explanations for this phenomenon vary. They range from gender-gap issues (95% of nurses worldwide are women), insufficient pay and recognition, quality of patient care, and the past decade's significant changes in the health care industry. 相似文献
63.
64.
65.
Slaven EM Lopez F Weintraub SL Mena JC Mallon WK 《Emergency Medicine Clinics of North America》2003,21(4):987-1015
As the prevalence of HIV infection continues to increase, EPs will be called upon to evaluate increasing numbers of AIDS patients who have abdominal pain, some of whom will require emergent surgical intervention. In addition to the myriad causes of abdominal pain in the nonimmunocompromised patient, the differential diagnosis in the AIDS patient includes a wide variety of opportunistic infections and neoplasms (Table 5). Evaluation frequently requires extensive laboratory studies and cultures and advanced imaging (CT, ultrasound, and so forth). A low threshold for surgical and other subspecialty consultation should be in place because of the often subtle presentation of surgical emergencies in AIDS patients. 相似文献
66.
Powell CA Stanley CM Bannister SR McDonnell HT Moritz AJ Deas DE 《Journal of periodontology》2006,77(2):310-315
BACKGROUND: Neurofibromatosis type 1 (NF1) is the most common form of neurofibromatosis. While typically considered a dermatologic disorder, intraoral signs of neurofibromatosis occur quite commonly. This clinical entity can be confused with periodontitis because of the presence of periodontal pockets. In this report, we present the case of a palatal neurofibroma with radiographic involvement in a patient with NF1. METHODS: A 40-year-old female patient was referred from her general dentist to evaluate advanced periodontitis in the maxillary left quadrant. The patient's medical history was significant for a soft tissue lesion excised from her back 11 years previously and diagnosed as a neurofibroma. Subsequent medical examination at that time confirmed a systemic diagnosis of NF1. A comprehensive periodontal evaluation was performed, and panoramic and periapical radiographs were taken. Teeth were tested for vitality. An incisional biopsy was completed for histopathologic examination. RESULTS: The periodontal evaluation revealed the presence of 6 to 9 mm probing depths adjacent to teeth #14 and #15. Panoramic and periapical radiographs showed a circumscribed 0.8x0.9-cm unilocular radiolucency superimposed over the root of tooth #13 and extensive horizontal bone loss on the distal side of #15. Incisional biopsy confirmed the presence of a neurofibroma, and because of the extent of the lesion, the patient was referred to the Oral and Maxillofacial Surgery service for complete excision. CONCLUSIONS: Neurofibromas can cause extensive destruction of alveolar bone, mimicking periodontitis. Due to the potential systemic and genetic implications, the diagnosis of neurofibroma requires appropriate medical referral. 相似文献
67.
Lauren E. Ta DDS MS James C. Phero DMDdagger Stanley R. Pillemer MDDagger Hollie Hale-Donze PhDsect Nancy McCartney-Francis PhDpar Albert Kingman PhDpara Mitchell B. Max MDnum Sharon M. Gordon DDS MPH Sharon M. Wahl PhDdaggerdagger Raymond A. Dionne DDS PhDDaggerDagger 《Journal of oral and maxillofacial surgery》2002,60(12):1389-1399
PURPOSE: An undetermined number of patients with temporomandibular joint (TMJ) symptoms have been treated with intra-articular disc implants composed of Teflon ethylene/propylene or Teflon polytetrafluoroethylene and aluminum oxide (Proplast-Teflon; Vitek, Houston, TX). These implants have shown the potential to fragment in situ resulting in nonbiodegradable particles that stimulate a giant cell reaction and lead to degeneration of local structures, pain, and limitation of mandibular opening. We examined the possible relationship between TMJ implants and persistent pain, responses to sensory stimuli, quality of life, and systemic immune dysfunction. PATIENTS AND METHODS: This case series (32 patients) were referred from university-based orofacial pain centers and private practices from across the United States. Laboratory and clinical assessments evaluated orofacial pain symptoms, neurologic function, clinical signs and symptoms of rheumatologic disease, physical function, systemic measures of immune function, and behavioral measures. RESULTS: We found that TMJ implant patients appeared to have altered sensitivity to sensory stimuli, a higher number of tender points with a diagnosis of fibromyalgia, increased self-report of chemical sensitivity, higher psychologic distress and significantly lower functional ability. Systemic illness or autoimmune disease was not evident in this series of TMJ implant patients. CONCLUSIONS: Significant problems were noted on clinical assessment of TMJ implant patients. This is a US government work. There are no restrictions on its use. 相似文献
68.
Gordon SM Heft MW Dionne RA Jeffcoat MK Alfano MC Valachovic RW Lipton JA 《Journal of dental education》2003,67(6):622-629
The ability to base patient care on scientific evidence depends in part on the results of translational and applied research. The shortage of trained clinical researchers identified by several sources limits the availability of clinical research studies upon which to base evidence-based therapeutics. This premise suggests that the dental profession needs to train more clinical researchers and faculty to conduct clinical research and to teach its applications to practice. Increasing opportunities for clinical research training in a variety of settings should eventually increase the numbers of clinical researchers, raise faculty involvement in clinical research, and promote science transfer. This paper reports on the current status of clinical research in dental schools, specifies the diverse groups involved in the clinical research enterprise, and identifies underutilized opportunities and partnerships for clinical research training. Data on federal and nonfederal funding of clinical research and training programs are presented. Existing and novel mechanisms for expanding clinical research training throughout and across traditional as well as unconventional environments are explored. 相似文献
69.
The Validity of Self-reported Oral Health Status in the Elderly 总被引:4,自引:0,他引:4
Chester W. Douglass DMD PhD Jesse Berlin ScD Sharon Tennstedt PhD 《Journal of public health dentistry》1991,51(4):220-222
The validity of self-reported number of teeth was assessed in a random sample of 50 individuals aged 70+ by comparing self-reports in a telephone interview with results of a subsequent in-home examination by a dentist. There were no significant differences between self-report and examination data, nor was there any systematic under- or over-counting of teeth as the actual number of teeth increased. These data support the validity of self-reported dentition. 相似文献
70.
Abstract – To evaluate the frequency and causes of dental and maxillofacial trauma in hospitalized patients. From January 1, 2000 to December 31, 2003, data from hospitalized trauma patients in a level 1 trauma center in Israel were analyzed according to age, gender, time, place, and cause of injury. Maxillofacial and tooth injuries were separated and further analyzed according to the above parameters. The analysis was based on data from the Israel Trauma Registry (ITR). Of all 14 040 trauma patients, 1038 (7.4%) involved maxillofacial or dental injuries. Common causes of injury were motor vehicle crashes (41%), falls (27%) and intentional injuries (23%). Fifty percent occurred on the street/road, 17% at home and 14% in public buildings. Surgery was required in 55.5% of all maxillofacial injuries. Males were hospitalized three times more than females, and young people, ages 19–28, were at greatest risk (30.2%). Oral and maxillofacial trauma is common, requiring dental health training for primary caregivers. 相似文献